General Information
PTM Description
(3R,4R)-3,4-dihydroxyproline
Modified Amino Acid
P
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
O2
Monoisotopic Mass Difference
31.9898
Average Mass Difference
32
Localization
extracellular and lumenal localisation [Detail]
RESID IDAA0479
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites1



General Information
PTM Description
(3R,4S)-3,4-dihydroxyproline
Modified Amino Acid
P
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
O2
Monoisotopic Mass Difference
31.9898
Average Mass Difference
32
Localization
extracellular and lumenal localisation [Detail]
RESID IDAA0282
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites55
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A00.84000000.040.02000.780
R0000000000000
N0000000000000
D0000000000000
C0000000000000
G0000000000000
E0000000000000
Q0000000000000
H0000000000000
I0000.04000000000
L00.0200000000000
K1010000000100.98
M0000000000000
F0000000000000
P00.1500.950000.820000.130
S00000.85000.150.11000.070
T0000.020.150000.87000.020.02
W0000000000000
Y0000010001000
V0000000000000
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
3,4-dihydroxyproline
Modified Amino Acid
P
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
O2
Monoisotopic Mass Difference
31.9898
Average Mass Difference
32
Localization
extracellular and lumenal localisation [Detail]
RESID IDAA0282
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites57
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A00.82000000.040.02000.770
R0000000000000
N000000000000.020
D0000000000000
C0000.02000000000.02
G000.0200000.020.020.02000
E0000000000000
Q0000000000000
H0000000000000
I0000.04000000000
L00.0200000000000
K0.9800.9800000000.9800.96
M0000000000000
F0000000000000
P00.1600.930000.80000.130
S00000.840.0200.140.1100.020.070
T0.02000.020.160000.86000.020.02
W0000000000000
Y000000.980000.98000
V0000000000000
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
3-hydroxyproline
Modified Amino Acid
P
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
O1
Monoisotopic Mass Difference
15.9949
Average Mass Difference
16
Localization
extracellular and lumenal localisation [Detail]
RESID IDAA0029
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites25
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.160.08000.1600000.080.1600.04
R0.040.0400.20.04000000.1600.16
N00.040.040.04000000.080.0800.08
D0.040.0800.040.04000.0400.040.040.040.12
C0000000000000
G00.040.8800.120.8800.040.8800.080.80.04
E0.1200.040.0400000000.040.12
Q00.200.08000000000
H0000000000000
I0.080.04000.1200000.0800.040.04
L0.2000.16000000000.04
K00.0800.0400000.040000
M0.04000000000000
F0.04000000000000
P0.20.280.040.360.360.0400.880.040.640.2800.28
S0.040.0400.040.0800000.040.160.040
T00.080000000.040000.04
W000000000000.040
Y000000.0400.0400000.04
V0.040000.080.040000.040.0400
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
4-hydroxyproline
Modified Amino Acid
P
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
O1
Monoisotopic Mass Difference
15.9949
Average Mass Difference
16
Localization
extracellular and lumenal localisation [Detail]
RESID IDAA0030
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites969
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.160.050.090.150.090.1200.040.10.120.080.110.08
R0.070.010.030.090.010.0300.010.020.0600.040.07
N0.0200.020.0300.01000.010.0100.020.02
D0.030.010.030.0300.01000.020.060.020.040.04
C0.0100.010000000000
G0.030.590.040.020.610.0300.620.040.030.590.050.03
E0.0200.10.020.010.05000.070.020.010.070.02
Q0.070.010.030.050.010.02000.020.040.010.030.04
H0.0100.01000.01000.02000.010.01
I0.0200.030.0200.0300.010.020.020.010.020.03
L0.030.020.050.020.020.06000.030.0100.050.01
K0.060.080.020.110.010.0900.010.030.150.010.090.05
M0.0100.010.0200.03000.020.010.010.010.01
F000.020.0100.04000.020.0100.020
P0.310.050.280.210.10.3200.070.260.310.160.220.32
S0.070.040.060.130.030.0900.110.060.070.050.070.08
T0.050.110.030.050.020.0300.110.030.050.030.120.06
W0000000000000
Y0.020.010.10.010.080.0100.010.170.010.010.010.09
V0.030.020.040.040.010.0300.010.040.040.020.030.04
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
Hydroxyproline
Modified Amino Acid
P
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
O1
Monoisotopic Mass Difference
15.9949
Average Mass Difference
16
Localization
extracellular and lumenal localisation [Detail]
RESID IDnone
Substrate Site Specificity
Number of Experimentally Validated Sites1257
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.130.090.080.130.070.1100.030.090.110.060.150.08
R0.080.010.030.10.010.0300.010.020.060.010.040.08
N0.020.010.020.0200.01000.010.0200.020.02
D0.030.010.030.0300.01000.020.060.010.030.04
C000.0100000.01000.0100
G0.030.580.070.030.60.0500.610.070.030.580.070.03
E0.0200.090.020.010.05000.070.0100.070.02
Q0.060.010.030.050.010.02000.020.0500.020.05
H000.01000.01000.02000.010.01
I0.0200.030.020.010.0300.010.020.010.010.020.02
L0.030.020.050.020.020.06000.040.0100.060.01
K0.120.060.090.090.010.0700.010.040.130.070.070.12
M0.0200.010.0200.02000.010.010.010.010.01
F000.02000.04000.02000.020
P0.30.060.250.280.080.2800.130.250.290.130.210.29
S0.050.030.050.10.080.0700.10.060.060.040.060.07
T0.040.080.030.040.030.0300.080.080.040.030.080.05
W0000000000000
Y0.020.010.070.010.060.0700.010.120.0700.020.07
V0.030.010.040.030.020.0300.010.040.030.020.030.03
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo