General Information
PTM Description
Lysine methyl ester
Modified Amino Acid
K
Position of Modification on Amino Acid
protein backbone
Position in the Polypeptide
C-terminal carboxyl group
Correction Formula
C1;H2
Monoisotopic Mass Difference
14.0156
Average Mass Difference
14.03
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0318
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites1
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10
A1001100
R0000000
N0000000
D0000000
C0000000
G0000000
E0000000
Q0100000
H0000000
I0000000
L0000000
K0010010
M0000000
F0000000
P0000000
S0000000
T0000000
W0000000
Y0000000
V0000000
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
N6,N6,N6-trimethyllysine
Modified Amino Acid
K
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C3;H6
Monoisotopic Mass Difference
42.047
Average Mass Difference
42.08
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0074
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites234
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.140.10.040.140.250.0200.070.110.010.090.010.22
R0.020.010.020.0600.2700.0300.070.120.110.06
N000.140.040.16000.010.010.0100.030.02
D0.120.03000.030.0400.020.050.110.10.020.02
C00.0100000000000
G0.040.040.020.10.320.02000.050.110.140.180.11
E0.090.020.010.040.010.1200.010.020.020.150.120.02
Q00.010.110.0400.0200.030.030.0800.030.04
H000.010.010.020000.010.06000
I0.030.070.030.010.020.0200.020.030.150.0100.05
L0.020.030.150.210.030.1100.10.060.050.030.040.04
K0.060.140.150.010.020.0100.30.020.030.080.160.02
M0.2100.0200000.010.010.02000
F0.0100.100.010.0800.020.030.010.010.040.02
P0.070.020.010.110.040.15000.180.160.170.020.01
S0.010.040.060.020.05000.2300.040.050.040.01
T0.10.210.060.1400.0100.050.230.020.020.110.16
W000000.0200.0100.01000
Y00.1500.020.020.0100.010.14000.070.08
V0.070.10.030.050.010.0800.050.020.030.0200.12
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
N6,N6-dimethyllysine
Modified Amino Acid
K
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C2;H4
Monoisotopic Mass Difference
28.0313
Average Mass Difference
28.06
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0075
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites251
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.140.10.070.120.280.0300.120.170.040.10.060.15
R0.060.020.010.030.010.2800.020.030.080.170.030.12
N0.030.020.030.040.030.0200.0100.010.010.040.08
D0.080.060.040.040.060.0300.030.080.020.060.040.01
C0000000000.01000
G0.050.020.120.140.130.0800.040.030.20.150.040.14
E0.090.080.050.040.04000.040.050.060.10.020.02
Q0.020.020.120.050.030.0300.020.020.020.020.040.06
H00.02000.040.0100.010.010.100.010.01
I0.030.10.020.080.030.02000.040.060.070.030.05
L0.050.040.050.040.080.0500.080.070.090.010.050.09
K0.040.170.160.070.050.1300.160.050.020.070.140.03
M0.0200.0100.01000.010.060.020.020.070.02
F0.010.020.010.020.010.08000.020.0200.090.04
P0.120.040.040.040.010.0400.050.130.120.030.010.04
S0.060.080.090.080.140.0600.280.010.080.060.070.04
T0.120.170.120.150.020.0100.070.140.010.030.120.03
W0.01000000000.01000
Y0.010.020.010.020000.020.020.010.050.080
V0.050.020.040.030.040.100.050.050.030.040.050.06
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
N6-methylated lysine
Modified Amino Acid
K
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C3;H6
Monoisotopic Mass Difference
42.047
Average Mass Difference
42.08
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDnone
Substrate Site Specificity
Number of Experimentally Validated Sites57
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.230.120.090.210.330.0400.140.210.090.180.110.19
R0.020.050.070.040.040.400.020.040.050.050.040.04
N0.020.050.0200.09000.050.0400.020.020.02
D00.020.050.050.020.0200.020.040.050.050.050.11
C000.04000.040000000.02
G0.110.120.050.110.190.0700.050.070.190.1600.12
E0.050.110.0400.020.0700.050.1100.050.090
Q000.1400000.040.040.0500.040
H0.020.020.0400.040.020000.040.0200
I0.02000.020.02000.0200.070.070.050.02
L0.0400.050.1600.0900.050.040.050.0200.04
K0.050.190.190.050.090.1200.140.050.120.050.180.19
M0.040000000.05000.020.020
F000.0500000.020.040.020.040.090.04
P0.110.070.040.070.040000.070.110.090.070.04
S0.050.120.050.070.040.0400.210.050.090.050.040.04
T0.140.120.040.190.050.0500.040.180.020.020.140.04
W0.0200000000.020000
Y0.0400.0400000000.050.040
V0.0700.020.040.050.0500.110.040.050.070.050.12
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
N6-methyllysine
Modified Amino Acid
K
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C1;H2
Monoisotopic Mass Difference
14.0156
Average Mass Difference
14.03
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0076
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites441
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.140.120.090.140.220.0900.090.160.080.10.080.16
R0.080.030.050.080.030.2400.030.030.10.120.050.09
N0.030.030.020.030.030.0100.020.020.020.010.040.02
D0.010.030.040.030.060.0200.050.060.040.060.050.04
C0.010.010.01000.010000.01000
G0.10.060.080.120.120.0400.050.040.150.090.050.17
E0.080.050.040.080.040.0500.030.050.050.070.10.03
Q0.020.020.10.040.020.0300.080.010.050.020.030.05
H0.010.010.010.010.05000.030.030.090.010.020.01
I0.020.060.020.040.030.0100.010.050.030.040.020.06
L0.070.040.030.110.080.0800.050.120.070.060.050.05
K0.050.150.180.070.060.0600.130.060.070.090.150.08
M0.040.010.0100.020.0100.010.020000
F0.010.010.010.0100.0800.010.020.040.030.060.01
P0.080.080.040.030.060.0600.040.10.080.040.010.05
S0.060.060.070.040.040.0500.190.040.030.10.070.04
T0.10.140.090.090.040.0600.060.130.020.080.090.06
W000000.01000.0100.010.010
Y0.040.020.050.030.020.0100.020.010.010.030.070.02
V0.040.070.070.040.070.0700.080.060.080.040.040.05
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
N6-poly(methylaminopropyl)lysine
Modified Amino Acid
K
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C24;H54;N6
Monoisotopic Mass Difference
426.441
Average Mass Difference
426.73
Localization
extracellular and lumenal localisation [Detail]
RESID IDAA0278
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites12
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0000000000000
R0.50.5000000.420.42000.080.08
N000.170000000.17000
D0000000000000
C0000000000000
G00.420.0800.4200000.58000.08
E0000000000000
Q0000000000000
H0000000000000
I000.330000000.25000
L0000.50000000.4200
K0000.420000.5800000
M0000000000000
F0000000000000
P0000000000000
S0.420.080.4200.580.92000.5800.580.420.83
T000000.080000000
W0000000000000
Y0.08000.0800000000.50
V0000000000000
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo