General Information
PTM Description
5-methylarginine
Modified Amino Acid
R
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C1;H2
Monoisotopic Mass Difference
14.0156
Average Mass Difference
14.03
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0272
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites383
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.030.090.050.060.10.0500.070.070.080.060.060.05
R0.150.10.190.090.180.0600.040.220.070.180.090.14
N0.020.030.030.030.010.0300.010.010.030.020.030.04
D0.050.030.030.020.030.0700.020.020.030.040.040.05
C0000.010.010000.010000
G0.250.260.180.290.230.3200.560.310.230.220.290.21
E0.040.040.040.020.050.0200.020.020.040.040.030.04
Q0.050.050.030.050.020.0400.020.040.020.040.050.05
H0.010.010.0100.010.0100.010.020.020.010.030.01
I0.030.020.020.010.020.0300.010.020.010.010.020.01
L0.050.030.050.030.030.0500.050.060.070.040.040.05
K0.040.020.040.050.030.0200.030.030.020.040.040.06
M0.030.030.020.030.030.0100.020.010.040.020.020.03
F0.020.050.030.050.010.0300.020.030.090.030.040.06
P0.080.050.10.080.080.100.060.050.080.080.070.06
S0.060.10.080.090.080.100.020.030.080.060.070.07
T0.040.020.040.020.010.0200.010.030.020.030.050.02
W000000000.010000.02
Y0.030.030.060.030.030.0200.010.010.050.030.010.02
V0.030.040.020.040.040.0200.020.030.030.050.030.02
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
Asymmetric dimethylarginine
Modified Amino Acid
R
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C2;H4
Monoisotopic Mass Difference
28.0313
Average Mass Difference
28.05
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0068
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites166
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A00.020.020.010.30.0200.0300.020.050.020.02
R0.20.040.130.40.110.0300.080.150.10.130.050.08
N0.010.460.010.020.090.0100.010.010.0100.040.02
D0.020.020.010.010.020.0700.0100.030.020.020.03
C000.2500000000.260.180
G0.370.260.180.160.320.1800.40.30.340.20.210.16
E0.010.010.0200.0100000000.01
Q00.010000.1500.010.060.010.010.010.01
H000000.010000.010.0100
I00.0100.0100.02000.090.070.0100
L0.02000.010.010.010000.0800.010.02
K0.110.010.010.210.010.0100.420.220.010.20.030.3
M0.030.030.040.010.030.02000.020.010.010.010.02
F0.020.010.210.050.010.0200.010.010.070.010.020.19
P0.060.060.050.040.020.3900.010.020.070.030.030.05
S0.050.040.040.040.040.0500.010.010.030.030.050.04
T0.070.0100.010.01000.010.070.010.010.060.01
W00000000000.010.250.01
Y0.030.010.020.0100.0100.010.020.030.030.010.02
V0.0100.010.010.01000.010.010.1300.010.01
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
Dimethylated arginine
Modified Amino Acid
R
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C2;H4
Monoisotopic Mass Difference
28.0313
Average Mass Difference
28.05
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDnone
Substrate Site Specificity
Number of Experimentally Validated Sites33
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A00.060.10.10.10.0300.030.160.10.060.030.06
R0.10.10.060.130.10.0600.060.060.060.060.10.03
N0.030.10.1000.03000.030.030.060.060.03
D000.030.030.030.030000.030.0300.03
C0000000000.030.0300.03
G0.190.350.060.230.190.3200.740.480.230.350.350.32
E0.060.060.030.060.060.0300.0300.030.10.030.06
Q0.060.030.0300.030.030000.030.030.030.06
H00.030.0300.03000.030.030.0300.030
I0.0300000000.030.030.0300
L0.0300.060.030.030.03000.10.03000.03
K00.030.030.0300000.03000.030.03
M0.0300.030.060.03000.030000.030
F0.030.030.10.1000000.060.10.030.1
P0.060.030.100.060.100.0300.060.10.10
S0.10.030.130.160.230.2300.030.030.100.030.1
T0.130.030.030.0600.03000000.060.03
W0000000000000.03
Y0.060.10.0300.060.060000.1300.060
V0.0600.0300.030000.0300.0300.03
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
N2,N2-dimethylarginine
Modified Amino Acid
R
Position of Modification on Amino Acid
protein backbone
Position in the Polypeptide
N-terminal amino group
Correction Formula
C2;H4
Monoisotopic Mass Difference
28.0313
Average Mass Difference
28.06
Localization
extracellular and lumenal localisation [Detail]
RESID IDAA0569
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites292
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.0+1+2+3+4+5+6
A00.060.050.070.050.070.05
R00.010.250.080.190.080.17
N00.010.030.030.030.050.04
D00.030.010.030.020.040.03
C000.01000.010
G00.630.330.260.260.30.22
E00.020.010.030.020.030.04
Q00.010.030.030.040.040.02
H000.010.010.010.010.01
I00.020.010.010.010.020.01
L00.030.030.050.040.020.04
K00.030.030.020.030.040.05
M000.020.030.020.020.03
F00.020.010.10.030.050.05
P00.040.030.110.060.050.07
S00.020.050.060.040.090.07
T00.020.040.030.030.030.04
W00.01000.0100.01
Y00.020.040.020.050.020.03
V00.030.020.030.030.030.03
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
N5-methylarginine
Modified Amino Acid
R
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C1;H2
Monoisotopic Mass Difference
14.0156
Average Mass Difference
14.03
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0305
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites2



General Information
PTM Description
Omega-N-methylarginine
Modified Amino Acid
R
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C1;H2
Monoisotopic Mass Difference
14.0156
Average Mass Difference
14.03
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0069
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites64
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.040.060.060.080.020.04000.080.060.060.060.08
R0.040.020.130.120.150.04000.130.060.150.080.19
N0.020.020.02000000.020.020.040.060.02
D0.020.020.040.020.020.0400.02000.040.020.04
C0000.02000000.02000.02
G0.290.190.080.350.210.4400.790.270.150.210.290.15
E0.080.060.080.020.04000.060.020.040.0600.02
Q0.060.060.130.020.020.02000.020.0800.020.06
H00.02000000.020.040000
I0.0200.0400.020000.020.020.020.040.02
L0.040.040.040.020.060.06000.170.040.1700.08
K00.040.020.10.150.0200.020.0600.040.120.02
M0.020.080.020.020.080.04000.040.100.020.04
F0.040.020.040.0400.0600.0200.10.0800.08
P0.190.020.150.10.040.1200.060.040.080.040.060.04
S0.040.190.060.120.10.0800.020.020.170.060.130.08
T0.080.120.0600.020.06000.0600.020.080.04
W0000000000000.02
Y00.02000.0200000.04000
V0.040.040.0400.060000.020.040.020.040.02
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
Omega-N-methylated arginine
Modified Amino Acid
R
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C2;H4
Monoisotopic Mass Difference
28.0313
Average Mass Difference
28.06
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDnone
Substrate Site Specificity
Number of Experimentally Validated Sites64
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.040.130.070.050.150.0400.050.050.090.050.050.04
R0.160.110.130.050.070.0700.020.20.040.070.040.11
N0.020.040.0500.020.0400.020.040.040.020.070.02
D0.040.040.020.020.040.0200.0400.050.110.020.05
C000.02000000.02000.020
G0.150.180.150.180.180.2500.470.290.240.180.180.16
E0.050.020.020.050.04000.040.050.050.0500.04
Q0.090.040.040.150.020.1100.020.0200.090.090.07
H00.070.0900.020.02000.0400.020.020.02
I0.020.020.020.040.050000.0200.020.040.02
L0.0500.0400.020.0900.070.070.090.040.040.05
K0.050.040.050.020.040.0400.020.020.020.050.020.07
M0.020.040.040.0400.0400.0200.070.020.020.04
F0.020.040.040.0700.0400.090.040.070.020.070.11
P0.110.050.090.070.150.0900.040.020.090.070.050.02
S0.050.090.090.130.090.1100.020.040.130.090.160.09
T0.020.020.020.050000.040.0500.020.040.02
W000000000.020000.02
Y0.020.020.040.040.050.0400.02000.020.020
V0.090.0700.040.070.0200.040.020.020.050.050.05
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



General Information
PTM Description
Symmetric dimethylarginine
Modified Amino Acid
R
Position of Modification on Amino Acid
amino-acid side chain
Position in the Polypeptide
any position
Correction Formula
C2;H4
Monoisotopic Mass Difference
28.0313
Average Mass Difference
28.06
Localization
cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID IDAA0067
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites191
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.020.030.020.010.280.0400.0300.030.060.030.02
R0.20.050.130.350.10.0300.070.140.090.110.040.11
N0.010.40.010.020.080.0100.010.020.0100.040.02
D0.020.020.010.010.020.0600.0100.030.020.020.03
C000.2200000000.220.160
G0.340.240.170.20.280.2300.430.260.310.20.20.14
E0.010.010.020.010.01000.010.010.010.0100.02
Q00.010.040.0200.1300.010.060.010.010.010.02
H000000.0100.0100.010.0100.01
I0.010.0200.010.010.02000.080.060.0100
L0.020.0100.010.020.01000.050.070.050.020.02
K0.090.010.020.180.050.0100.390.20.010.180.030.28
M0.020.030.030.020.030.02000.030.010.010.010.02
F0.020.010.190.050.020.0200.010.010.060.010.020.17
P0.090.050.060.030.020.3400.010.020.060.020.050.05
S0.050.080.040.060.030.0500.010.030.060.030.090.04
T0.060.0300.010.030.0100.010.070.030.020.060.02
W00000000.01000.010.220.01
Y0.030.010.020.0100.0100.010.020.030.020.010.02
V0.0100.010.020.02000.010.010.1100.010.01
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo