PTM General Information
PTM Description Lysine methyl ester
Modified Amino Acid K
Position of Modification on Amino Acid protein backbone
Position in the Polypeptide C-terminal carboxyl group
Correction Formula C1;H2
Monoisotopic Mass Difference 14.0156
Average Mass Difference 14.03
Localization cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID ID AA0318
Formula Structure
Formula 3D Structure



PTM Description N6,N6,N6-trimethyllysine
Modified Amino Acid K
Position of Modification on Amino Acid amino-acid side chain
Position in the Polypeptide any position
Correction Formula C3;H6
Monoisotopic Mass Difference 42.047
Average Mass Difference 42.08
Localization cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID ID AA0074
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites279
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.140.10.040.140.250.0200.070.110.010.090.010.22
R0.020.010.020.0600.2700.0300.070.120.110.06
N000.140.040.16000.010.010.0100.030.02
D0.120.03000.030.0400.020.050.110.10.020.02
C00.0100000000000
G0.040.040.020.10.320.02000.050.110.140.180.11
E0.090.020.010.040.010.1200.010.020.020.150.120.02
Q00.010.110.0400.0200.030.030.0800.030.04
H000.010.010.020000.010.06000
I0.030.070.030.010.020.0200.020.030.150.0100.05
L0.020.030.150.210.030.1100.10.060.050.030.040.04
K0.060.140.150.010.020.0100.30.020.030.080.160.02
M0.2100.0200000.010.010.02000
F0.0100.100.010.0800.020.030.010.010.040.02
P0.070.020.010.110.040.15000.180.160.170.020.01
S0.010.040.060.020.05000.2300.040.050.040.01
T0.10.210.060.1400.0100.050.230.020.020.110.16
W000000.0200.0100.01000
Y00.1500.020.020.0100.010.14000.070.08
V0.070.10.030.050.010.0800.050.020.030.0200.12
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



PTM Description N6,N6-dimethyllysine
Modified Amino Acid K
Position of Modification on Amino Acid amino-acid side chain
Position in the Polypeptide any position
Correction Formula C2;H4
Monoisotopic Mass Difference 28.0313
Average Mass Difference 28.06
Localization cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID ID AA0075
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites182
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.140.10.070.120.280.0300.120.170.040.10.060.15
R0.060.020.010.030.010.2800.020.030.080.170.030.12
N0.030.020.030.040.030.0200.0100.010.010.040.08
D0.080.060.040.040.060.0300.030.080.020.060.040.01
C0000000000.01000
G0.050.020.120.140.130.0800.040.030.20.150.040.14
E0.090.080.050.040.04000.040.050.060.10.020.02
Q0.020.020.120.050.030.0300.020.020.020.020.040.06
H00.02000.040.0100.010.010.100.010.01
I0.030.10.020.080.030.02000.040.060.070.030.05
L0.050.040.050.040.080.0500.080.070.090.010.050.09
K0.040.170.160.070.050.1300.160.050.020.070.140.03
M0.0200.0100.01000.010.060.020.020.070.02
F0.010.020.010.020.010.08000.020.0200.090.04
P0.120.040.040.040.010.0400.050.130.120.030.010.04
S0.060.080.090.080.140.0600.280.010.080.060.070.04
T0.120.170.120.150.020.0100.070.140.010.030.120.03
W0.01000000000.01000
Y0.010.020.010.020000.020.020.010.050.080
V0.050.020.040.030.040.100.050.050.030.040.050.06
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



PTM Description N6-methylated lysine
Modified Amino Acid K
Position of Modification on Amino Acid amino-acid side chain
Position in the Polypeptide any position
Correction Formula C3;H6
Monoisotopic Mass Difference 42.047
Average Mass Difference 42.08
Localization cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID ID none
Substrate Site Specificity
Number of Experimentally Validated Sites17
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.230.120.090.210.330.0400.140.210.090.180.110.19
R0.020.050.070.040.040.400.020.040.050.050.040.04
N0.020.050.0200.09000.050.0400.020.020.02
D00.020.050.050.020.0200.020.040.050.050.050.11
C000.04000.040000000.02
G0.110.120.050.110.190.0700.050.070.190.1600.12
E0.050.110.0400.020.0700.050.1100.050.090
Q000.1400000.040.040.0500.040
H0.020.020.0400.040.020000.040.0200
I0.02000.020.02000.0200.070.070.050.02
L0.0400.050.1600.0900.050.040.050.0200.04
K0.050.190.190.050.090.1200.140.050.120.050.180.19
M0.040000000.05000.020.020
F000.0500000.020.040.020.040.090.04
P0.110.070.040.070.040000.070.110.090.070.04
S0.050.120.050.070.040.0400.210.050.090.050.040.04
T0.140.120.040.190.050.0500.040.180.020.020.140.04
W0.0200000000.020000
Y0.0400.0400000000.050.040
V0.0700.020.040.050.0500.110.040.050.070.050.12
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo



PTM Description N6-methyllysine
Modified Amino Acid K
Position of Modification on Amino Acid amino-acid side chain
Position in the Polypeptide any position
Correction Formula C1;H2
Monoisotopic Mass Difference 14.0156
Average Mass Difference 14.03
Localization cytoplasm, nucleus, mitochondrial matrix, etc. [Detail]
RESID ID AA0076
Formula Structure
Formula 3D Structure
Substrate Site Specificity
Number of Experimentally Validated Sites8067
The Matrix of Positional Amino Acid Frequency Surrounding Modified Site
Pos.-6-5-4-3-2-10+1+2+3+4+5+6
A0.140.120.090.140.220.0900.090.160.080.10.080.16
R0.080.030.050.080.030.2400.030.030.10.120.050.09
N0.030.030.020.030.030.0100.020.020.020.010.040.02
D0.010.030.040.030.060.0200.050.060.040.060.050.04
C0.010.010.01000.010000.01000
G0.10.060.080.120.120.0400.050.040.150.090.050.17
E0.080.050.040.080.040.0500.030.050.050.070.10.03
Q0.020.020.10.040.020.0300.080.010.050.020.030.05
H0.010.010.010.010.05000.030.030.090.010.020.01
I0.020.060.020.040.030.0100.010.050.030.040.020.06
L0.070.040.030.110.080.0800.050.120.070.060.050.05
K0.050.150.180.070.060.0600.130.060.070.090.150.08
M0.040.010.0100.020.0100.010.020000
F0.010.010.010.0100.0800.010.020.040.030.060.01
P0.080.080.040.030.060.0600.040.10.080.040.010.05
S0.060.060.070.040.040.0500.190.040.030.10.070.04
T0.10.140.090.090.040.0600.060.130.020.080.090.06
W000000.01000.0100.010.010
Y0.040.020.050.030.020.0100.020.010.010.030.070.02
V0.040.070.070.040.070.0700.080.060.080.040.040.05
Sequence Logo

Average Solvent Accessibility Surrounding Modified Site
Secondary Structure Logo




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