UniProt ID | 1A02_HUMAN | |
---|---|---|
UniProt AC | P01892 | |
Protein Name | HLA class I histocompatibility antigen, A-2 alpha chain | |
Gene Name | HLA-A | |
Organism | Homo sapiens (Human). | |
Sequence Length | 365 | |
Subcellular Localization |
Membrane Single-pass type I membrane protein. | |
Protein Description | Involved in the presentation of foreign antigens to the immune system.. | |
Protein Sequence | MAVMAPRTLVLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEPSSQPTIPIVGIIAGLVLFGAVITGAVVAAVMWRRKSSDRKGGSYSQAASSDSAQGSDVSLTACKV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
110 | N-linked (GlcNAc) | GTLRGYYNQSEAGSH HHHCCCCCCCCCCCC | 30.34 | 19159218 | |
135 | N6-methyllysine | GSDWRFLRGYHQYAY CCCCHHHCCCEEEEE | 40.69 | 115478757 | |
145 | Ubiquitinlysine | HQYAYDGKDYIALKE EEEEECCCCEEEEHH | 44.45 | 21906983 21890473 | |
151 | Ubiquitinlysine | GKDYIALKEDLRSWT CCCEEEEHHHHHHCH | 39.91 | 21906983 21890473 | |
155 | N6-methyllysine | IALKEDLRSWTAADM EEEHHHHHHCHHHHH | 42.33 | 115478751 | |
168 | Ubiquitinlysine | DMAAQTTKHKWEAAH HHHHHHCHHHHHHHH | 46.72 | 21906983 21890473 | |
188 | S-glutathionyl cysteine | RAYLEGTCVEWLRRY HHHHHCHHHHHHHHH | 3.72 | 22555962 | |
200 | Ubiquitinlysine | RRYLENGKETLQRTD HHHHHCCHHHHHCCC | 60.14 | 21906983 21890473 | |
267 | N6-methyllysine | AGDGTFQKWAAVVVP CCCCCEEEEEEEEEC | 34.31 | 24623505 | |
267 | Ubiquitinlysine | AGDGTFQKWAAVVVP CCCCCEEEEEEEEEC | 34.31 | 21906983 21890473 | |
292 | Ubiquitinlysine | VQHEGLPKPLTLRWE EEECCCCCCEEEECC | 58.67 | 21906983 21890473 | |
340 | Ubiquitinlysine | RRKSSDRKGGSYSQA HCCCCCCCCCCCCCC | 73.03 | 21906983 21890473 | |
344 | Phosphotyrosine | SDRKGGSYSQAASSD CCCCCCCCCCCCCCC | 14.21 | 1956339 | |
350 | Phosphoserine | SYSQAASSDSAQGSD CCCCCCCCCCCCCCC | 30.75 | 24275569 | |
352 | Phosphoserine | SQAASSDSAQGSDVS CCCCCCCCCCCCCCE | 25.17 | 24275569 | |
356 | Phosphoserine | SSDSAQGSDVSLTAC CCCCCCCCCCEEEEE | 23.82 | 18088087 23186163 24275569 | |
359 | Phosphoserine | SAQGSDVSLTACKV- CCCCCCCEEEEECC- | 25.62 | 23186163 24275569 | |
364 | Ubiquitinlysine | DVSLTACKV------ CCEEEEECC------ | 48.81 | 21906983 21890473 |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 1A02_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
UGGG1_HUMAN | UGGT1 | physical | 17353931 | |
CD8A_HUMAN | CD8A | physical | 9177355 | |
CD8A_HUMAN | CD8A | physical | 10809759 | |
COPB_HUMAN | COPB1 | physical | 11884415 | |
COPG1_HUMAN | COPG1 | physical | 11884415 | |
TPSN_HUMAN | TAPBP | physical | 11884415 | |
TAP1_HUMAN | TAP1 | physical | 11884415 | |
SYVN1_HUMAN | SYVN1 | physical | 21245296 | |
UB2J1_HUMAN | UBE2J1 | physical | 21245296 | |
DERL1_HUMAN | DERL1 | physical | 21245296 | |
PSMD2_HUMAN | PSMD2 | physical | 21245296 | |
MAGA4_HUMAN | MAGEA4 | physical | 21815906 | |
BAP31_HUMAN | BCAP31 | physical | 17056546 | |
B2MG_HUMAN | B2M | physical | 8805302 | |
STAT3_HUMAN | STAT3 | physical | 21988832 | |
GNAS3_HUMAN | GNAS | physical | 9914489 | |
GNAS2_HUMAN | GNAS | physical | 9914489 | |
ALEX_HUMAN | GNAS | physical | 9914489 | |
GNAS1_HUMAN | GNAS | physical | 9914489 | |
BAG6_HUMAN | BAG6 | physical | 21636303 | |
MEOX2_HUMAN | MEOX2 | physical | 24722188 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
N-linked Glycosylation | |
Reference | PubMed |
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110, AND MASSSPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352 AND SER-356, ANDMASS SPECTROMETRY. | |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352 AND SER-356, ANDMASS SPECTROMETRY. |