AATM_MOUSE - dbPTM
AATM_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AATM_MOUSE
UniProt AC P05202
Protein Name Aspartate aminotransferase, mitochondrial
Gene Name Got2
Organism Mus musculus (Mouse).
Sequence Length 430
Subcellular Localization Mitochondrion matrix. Cell membrane.
Protein Description Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids..
Protein Sequence MALLHSSRILSGMAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
52N6-acetyllysineLGVTEAFKRDTNSKK
HHHHHHHHHHCCCCC
57.3123576753
23954790
52N6-succinyllysineLGVTEAFKRDTNSKK
HHHHHHHHHHCCCCC
57.3124315375
58N6-acetyllysineFKRDTNSKKMNLGVG
HHHHCCCCCCEEEEC
59.1023864654
23954790
59N6-acetyllysineKRDTNSKKMNLGVGA
HHHCCCCCCEEEECC
32.6123576753
59N6-glutaryllysineKRDTNSKKMNLGVGA
HHHCCCCCCEEEECC
32.6124703693
59N6-succinyllysineKRDTNSKKMNLGVGA
HHHCCCCCCEEEECC
32.6123806337
67PhosphotyrosineMNLGVGAYRDDNGKP
CEEEECCCCCCCCCC
14.5120495213
16381945
23193290
22135298
73N6-acetyllysineAYRDDNGKPYVLPSV
CCCCCCCCCCCCCHH
39.1623576753
23806337
73N6-glutaryllysineAYRDDNGKPYVLPSV
CCCCCCCCCCCCCHH
39.1624703693
75PhosphotyrosineRDDNGKPYVLPSVRK
CCCCCCCCCCCHHHH
20.3622135298
25195567
82N6-acetyllysineYVLPSVRKAEAQIAA
CCCCHHHHHHHHHHH
48.7123576753
82N6-malonyllysineYVLPSVRKAEAQIAA
CCCCHHHHHHHHHHH
48.7126320211
82N6-glutaryllysineYVLPSVRKAEAQIAA
CCCCHHHHHHHHHHH
48.7124703693
82N6-succinyllysineYVLPSVRKAEAQIAA
CCCCHHHHHHHHHHH
48.7123954790
26388266
90N6-acetyllysineAEAQIAAKNLDKEYL
HHHHHHHCCCCCCCC
49.3623576753
90N6-glutaryllysineAEAQIAAKNLDKEYL
HHHHHHHCCCCCCCC
49.3624703693
94N6-acetyllysineIAAKNLDKEYLPIGG
HHHCCCCCCCCCCCC
51.9616916647
22826441
23201123
96PhosphotyrosineAKNLDKEYLPIGGLA
HCCCCCCCCCCCCHH
24.4217242355
96Nitrated tyrosineAKNLDKEYLPIGGLA
HCCCCCCCCCCCCHH
24.4216800626
106 S-nitrosocysteineIGGLAEFCKASAELA
CCCHHHHHHHHHHHH
2.4422178444
22588120
24895380
20925432
21278135
107N6-acetyllysineGGLAEFCKASAELAL
CCHHHHHHHHHHHHC
51.1823576753
107N6-succinyllysineGGLAEFCKASAELAL
CCHHHHHHHHHHHHC
51.1823806337
122N6-acetyllysineGENNEVLKSGRFVTV
CCCCCCCCCCCEEEE
56.9123576753
122N6-glutaryllysineGENNEVLKSGRFVTV
CCCCCCCCCCCEEEE
56.9124703693
133PhosphoserineFVTVQTISGTGALRV
EEEEEEEECCCHHHH
33.4221183079
16381945
23193290
22135298
22817900
143PhosphoserineGALRVGASFLQRFFK
CHHHHHHHHHHHHCC
22.1421183079
16381945
23193290
22135298
21743459
22817900
150N6-acetyllysineSFLQRFFKFSRDVFL
HHHHHHCCCCCEEEE
39.4522309199
23576753
23864654
24062335
150N6-succinyllysineSFLQRFFKFSRDVFL
HHHHHHCCCCCEEEE
39.4526388266
159N6-acetyllysineSRDVFLPKPSWGNHT
CCEEEEECCCCCCHH
54.5623576753
23806337
159N6-malonyllysineSRDVFLPKPSWGNHT
CCEEEEECCCCCCHH
54.5626073543
26320211
159N6-succinyllysineSRDVFLPKPSWGNHT
CCEEEEECCCCCCHH
54.5623806337
166PhosphothreonineKPSWGNHTPIFRDAG
CCCCCCHHHHHHHHC
23.2921183079
16381945
23193290
19060867
22135298
23684622
22817900
185N6-acetyllysineGYRYYDPKTCGFDFS
EEEEEECCCCCCCHH
54.2523576753
185N6-succinyllysineGYRYYDPKTCGFDFS
EEEEEECCCCCCCHH
54.2523806337
187 S-nitrosocysteineRYYDPKTCGFDFSGA
EEEECCCCCCCHHHH
6.8022178444
22588120
24895380
19483679
20925432
21278135
187 S-glutathionyl cysteineRYYDPKTCGFDFSGA
EEEECCCCCCCHHHH
6.8024333276
192PhosphoserineKTCGFDFSGALEDIS
CCCCCCHHHHHHHHH
25.6322135298
23567750
212 S-nitrosocysteineSVLLLHACAHNPTGV
CEEEEEECCCCCCCC
2.4921278135
227N6-acetyllysineDPRPEQWKEIASVVK
CCCHHHHHHHHHHHH
38.6522733758
23576753
23806337
23864654
23954790
227N6-malonyllysineDPRPEQWKEIASVVK
CCCHHHHHHHHHHHH
38.6526320211
227N6-glutaryllysineDPRPEQWKEIASVVK
CCCHHHHHHHHHHHH
38.6524703693
227N6-succinyllysineDPRPEQWKEIASVVK
CCCHHHHHHHHHHHH
38.6523806337
231PhosphoserineEQWKEIASVVKKKNL
HHHHHHHHHHHHCCC
32.8622135298
234N6-acetyllysineKEIASVVKKKNLFAF
HHHHHHHHHCCCEEE
56.7423576753
234N6-malonyllysineKEIASVVKKKNLFAF
HHHHHHHHHCCCEEE
56.7426320211
234N6-glutaryllysineKEIASVVKKKNLFAF
HHHHHHHHHCCCEEE
56.7424703693
234N6-succinyllysineKEIASVVKKKNLFAF
HHHHHHHHHCCCEEE
56.7423806337
23954790
24315375
235N6-acetyllysineEIASVVKKKNLFAFF
HHHHHHHHCCCEEEE
34.9723576753
235N6-succinyllysineEIASVVKKKNLFAFF
HHHHHHHHCCCEEEE
34.9723954790
279N6-acetyllysineCLCQSYAKNMGLYGE
EEECCCHHHHCCHHH
38.9523576753
284PhosphotyrosineYAKNMGLYGERVGAF
CHHHHCCHHHHHHHH
15.9422135298
295 S-nitrosocysteineVGAFTVVCKDAEEAK
HHHHHHCCCCHHHHH
2.6122178444
24895380
20925432
21278135
295S-palmitoyl cysteineVGAFTVVCKDAEEAK
HHHHHHCCCCHHHHH
2.6128526873
295 S-glutathionyl cysteineVGAFTVVCKDAEEAK
HHHHHHCCCCHHHHH
2.6124333276
296N6-acetyllysineGAFTVVCKDAEEAKR
HHHHHCCCCHHHHHH
48.6523576753
296N6-malonyllysineGAFTVVCKDAEEAKR
HHHHHCCCCHHHHHH
48.6525418362
26073543
26320211
296N6-glutaryllysineGAFTVVCKDAEEAKR
HHHHHCCCCHHHHHH
48.6524703693
296N6-succinyllysineGAFTVVCKDAEEAKR
HHHHHCCCCHHHHHH
48.6523806337
302N6-acetyllysineCKDAEEAKRVESQLK
CCCHHHHHHHHHHHH
61.3223576753
302N6-glutaryllysineCKDAEEAKRVESQLK
CCCHHHHHHHHHHHH
61.3224703693
309N6-acetyllysineKRVESQLKILIRPLY
HHHHHHHHHHHHCCC
28.0323576753
309N6-malonyllysineKRVESQLKILIRPLY
HHHHHHHHHHHHCCC
28.0326073543
309N6-glutaryllysineKRVESQLKILIRPLY
HHHHHHHHHHHHCCC
28.0324703693
309N6-succinyllysineKRVESQLKILIRPLY
HHHHHHHHHHHHCCC
28.0323806337
313Asymmetric dimethylarginineSQLKILIRPLYSNPP
HHHHHHHHCCCCCCH
16.2424129315
333PhosphoserineIAATILTSPDLRKQW
HHHHHCCCHHHHHHH
16.9920415495
16381945
23193290
21081558
19060867
22135298
22817900
21183079
23984901
25338131
338N6-acetyllysineLTSPDLRKQWLQEVK
CCCHHHHHHHHHHHH
53.7923576753
338N6-malonyllysineLTSPDLRKQWLQEVK
CCCHHHHHHHHHHHH
53.7926073543
26320211
338N6-glutaryllysineLTSPDLRKQWLQEVK
CCCHHHHHHHHHHHH
53.7924703693
338N6-succinyllysineLTSPDLRKQWLQEVK
CCCHHHHHHHHHHHH
53.7923806337
345N6-acetyllysineKQWLQEVKGMADRII
HHHHHHHHHHHHHHH
42.0623576753
345N6-succinyllysineKQWLQEVKGMADRII
HHHHHHHHHHHHHHH
42.0623806337
23954790
24315375
26388266
360PhosphoserineSMRTQLVSNLKKEGS
HHHHHHHHHHHHCCC
45.0722135298
363N6-acetyllysineTQLVSNLKKEGSSHN
HHHHHHHHHCCCCCC
53.6923576753
363N6-glutaryllysineTQLVSNLKKEGSSHN
HHHHHHHHHCCCCCC
53.6924703693
364N6-acetyllysineQLVSNLKKEGSSHNW
HHHHHHHHCCCCCCC
71.1623576753
382 S-nitrosocysteineTDQIGMFCFTGLKPE
HHCCCCEEECCCCHH
1.9021278135
387N6-acetyllysineMFCFTGLKPEQVERL
CEEECCCCHHHHHHH
48.1023576753
387N6-succinyllysineMFCFTGLKPEQVERL
CEEECCCCHHHHHHH
48.1024315375
396N6-acetyllysineEQVERLTKEFSVYMT
HHHHHHHHHCCEEEC
62.4423576753
396N6-glutaryllysineEQVERLTKEFSVYMT
HHHHHHHHHCCEEEC
62.4424703693
399PhosphoserineERLTKEFSVYMTKDG
HHHHHHCCEEECCCC
17.2722135298
23567750
404N6-acetyllysineEFSVYMTKDGRISVA
HCCEEECCCCEEEEE
41.4723576753
23806337
404N6-glutaryllysineEFSVYMTKDGRISVA
HCCEEECCCCEEEEE
41.4724703693
415PhosphoserineISVAGVTSGNVGYLA
EEEECCCHHHHHHHH
26.4322135298
430N6-acetyllysineHAIHQVTK-------
HHHHHHHC-------
60.5323864654
24062335
430N6-succinyllysineHAIHQVTK-------
HHHHHHHC-------
60.5324315375
26388266

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference

Oops, there are no SNP-PTM records of AATM_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AATM_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-94; LYS-159; LYS-185;LYS-296; LYS-345 AND LYS-363, AND MASS SPECTROMETRY.
Nitration
ReferencePubMed
"Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease.";
Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.;
Biochemistry 45:8009-8022(2006).
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-96, AND MASS SPECTROMETRY.

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