ADCY7_HUMAN - dbPTM
ADCY7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADCY7_HUMAN
UniProt AC P51828
Protein Name Adenylate cyclase type 7
Gene Name ADCY7
Organism Homo sapiens (Human).
Sequence Length 1080
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description This is a membrane-bound, calcium-inhibitable adenylyl cyclase..
Protein Sequence MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
154PhosphoserineAVAVGAVSTASHLLV
CHHHHCCHHHHHHHH
20.0946159659
155PhosphothreonineVAVGAVSTASHLLVL
HHHHCCHHHHHHHHH
26.1146159677
157PhosphoserineVGAVSTASHLLVLGS
HHCCHHHHHHHHHHH
18.1146159665
365PhosphothreonineIKQVREATGVDINMR
HHHHHHHHCCCCEEE
32.7410486863
422N6-acetyllysineHITEATLKHLDKAYE
EEEHHHHHHHHHHEE
37.4520167786
426N6-acetyllysineATLKHLDKAYEVEDG
HHHHHHHHHEECCCC
60.2620167786
443UbiquitinlysineQQRDPYLKEMNIRTY
CCCCHHHHHCCCCEE
49.422189047
490PhosphoserineRMTRYLESWGAARPF
HHHHHHHHCCCCCCC
28.37101661943
505PhosphoserineAHLNHRESVSSGETH
CCCCCCCCCCCCCCC
27.5382900321
535PhosphoserineRTPDRSMSPKGRSED
CCCCCCCCCCCCCCC
25.38113310213
807PhosphotyrosineNFYLVLFYITLLTLS
HHHHHHHHHHHHHHH
6.7146159695
809PhosphothreonineYLVLFYITLLTLSRQ
HHHHHHHHHHHHHHH
12.3446159683
812PhosphothreonineLFYITLLTLSRQIDY
HHHHHHHHHHHHHHH
26.2946159689
814PhosphoserineYITLLTLSRQIDYYC
HHHHHHHHHHHHHHH
19.5346159671
892PhosphotyrosineVPDFKVFYTECDVNK
CCCEEEEEEECCCCH
12.4846159701
925PhosphoserineLLLKPKFSGVEKIKT
HHHCCCCCCCCCCEE
48.3225404012
1006UbiquitinlysineAGVIGARKPQYDIWG
EEEECCCCCCCCCCC
35.6221890473

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference
443Ubiquitination439 (4)DErs78534766
  • Ulcerative colitis:ulcerative colitis
28067908

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
XRCC6_HUMANXRCC6physical
21988832
PLS1_HUMANPLSCR1physical
21988832
BUD31_HUMANBUD31physical
21988832

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D01697 Colforsin daropate hydrochloride (JAN); Nkh 477; Adehl (TN)
DrugBank
There are no disease associations of PTM sites.
Related Literatures of Post-Translational Modification

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