Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Aflatoxin B1 aldehyde reductase member 2  

UniProtKB / Swiss-Prot ID :  ARK72_MOUSE

Gene Name (Synonyms) : 
Akr7a2, Afar, Akr7a5  

Species :  Mus musculus (Mouse). 

Subcellular Localization :  Golgi apparatus (By similarity). Cytoplasm (By similarity). 

Protein Function :  Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein- binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity). 

Protein Sequence MLRAASRAVGRAAVRSAQRSGTSVGRPLAMSRPPPPRAASGAPLRPATVLGTMEMGRRMDASASAASVRA...
Predicted Secondary Structure CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHH...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
40PhosphoserinePRAASGAPL
CCCCCCCEE
34.21PhosphoELM
Link-
40PhosphoserinePRAASGAPL
CCCCCCCEE
34.21Phosphositeplus
Link-
40PhosphoserinePRAASGAPL
CCCCCCCEE
34.21SysPTM
Link-
40Phosphoserine.PRAASGAPL
CCCCCCCEE
34.21UniProtKB
Link-
48PhosphothreonineLRPATVLGT
EEEEEEEEE
20.95PhosphoELM
Link
48PhosphothreonineLRPATVLGT
EEEEEEEEE
20.95Phosphositeplus
Link
48PhosphothreonineLRPATVLGT
EEEEEEEEE
20.95SysPTM
Link
48Phosphothreonine.LRPATVLGT
EEEEEEEEE
20.95UniProtKB
Link
53Methionine sulfoneVLGTMEMGR
EEEECCCCC
2.95SysPTM
Link
55Methionine sulfoneGTMEMGRRM
EECCCCCCC
3.34SysPTM
Link
136N6-acetyllysineETSLKRLQC
HHHHHHCCC
51.32Phosphositeplus
Link
222S-nitrosocysteineELLPCLRHF
HHHHHHHHC
5.42dbSNO
Link
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND THR-48, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures