Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  N-chimaerin  

UniProtKB / Swiss-Prot ID :  CHIN_HUMAN

Gene Name (Synonyms) : 
CHN1, ARHGAP2, CHN  

Species :  Homo sapiens (Human). 

Subcellular Localization :   

Protein Function :  GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. 

Protein Sequence MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSY...
Predicted Secondary Structure CCEECCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCE...
Protein Variant
LocationDescription
20L -> F (in DURS2; behaves as a dominantgain-of-function allele that increases
126I -> M (in DURS2; behaves as a dominantgain-of -function allele that increases
143Y -> H (in DURS2; behaves as a dominantgain-of-function allele that increases
223A -> V (in DURS2; behaves as a dominantgain-of-function allele that increases
228G -> S (in DURS2; behaves as a dominantgain-of-function allele that increases
252P -> Q (in DURS2; behaves as a dominantgain-of-function allele that increases
313E -> K (in DURS2; behaves as a dominantgain-of-function allele that increases
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
Protein Variant
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
2N-acetylalanine.---MALTLF
---CCEECC
14.84UniProtKB
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
RS3A_HUMANphysical interactionMINT-63479MINT16169070
TF3C1_HUMANphysical interactionEBI-734170
intact16169070
RS3A_HUMANphysical interactionEBI-734173
intact16169070
TGFR1_HUMANin vivoHPRD:00319HPRD15761153
RS3A_HUMANyeast 2-hybridHPRD:00319HPRD16169070
TF3C1_HUMANyeast 2-hybridHPRD:00319HPRD16169070
CD5R1_HUMANin vitro
in vivo
yeast 2-hybrid
HPRD:00319HPRD15013773
CDK5_HUMANin vitro
in vivo
yeast 2-hybrid
HPRD:00319HPRD15013773
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Disease Reference
Kegg disease
OMIM disease
604356Duane retraction syndrome 2 (DURS2)
Drug Reference
There are no disease associations of PTM sites.
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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures