Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Adapter molecule crk  

UniProtKB / Swiss-Prot ID :  CRK_RAT

Gene Name (Synonyms) : 
Crk, Crko  

Species :  Rattus norvegicus (Rat). 

Subcellular Localization :  Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. 

Protein Function :  The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (By similarity). 

Protein Sequence MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPP...
Predicted Secondary Structure CCCCCCCHHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCEEEEEEEECCCCEE...
Protein Variant
LocationDescription
244Q -> R (in NRK-23 inactive mutant).
253K -> E (in NRK-23 inactive mutant).
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
Protein Variant
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
221PhosphotyrosineEPGPYAQPS
CCCCCCCCC
24.63Phosphositeplus
Link-
221Phosphotyrosine; by ABL1.EPGPYAQPS
CCCCCCCCC
24.63UniProtKB
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Tyrosine 221 in Crk regulates adhesion-dependent membranelocalization of Crk and Rac and activation of Rac signaling.";
Abassi Y.A., Vuori K.;
EMBO J. 21:4571-4582(2002).
Cited for: PHOSPHORYLATION AT TYR-221, AND MUTAGENESIS OF TYR-221.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures