Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  L-xylulose reductase  

UniProtKB / Swiss-Prot ID :  DCXR_HUMAN

Gene Name (Synonyms) : 
DCXR  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Membrane; Peripheral membrane protein (By similarity). Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). 

Protein Function :  Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. 

Protein Sequence MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERA...
Predicted Secondary Structure CCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHH...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
1N-acetylmethionine.----MELFL
----CCCCC
10.22UniProtKB
Link
17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)TGAGKGIGR
ECCCCHHHH
46.98Phosphositeplus
Link
149PhosphotyrosineNHSVYCSTK
CCHHHHHHH
5.45HPRD
Link
149PhosphotyrosineNHSVYCSTK
CCHHHHHHH
5.45PhosphoELM
Link
149PhosphotyrosineNHSVYCSTK
CCHHHHHHH
5.45Phosphositeplus
Link
149Phosphotyrosine.NHSVYCSTK
CCHHHHHHH
5.45UniProtKB
Link
161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)DMLTKVMAL
HHHHHHHHH
26.50Phosphositeplus
Link
171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)LGPHKIRVN
HCCCCCEEE
35.03Phosphositeplus
Link
196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)SDPHKAKTM
CCHHHHHHH
57.90Phosphositeplus
Link
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
DCXR_HUMANin vitroHPRD:16320HPRD11882650
15103634
ALDR_HUMANENSP00000303356STRING
ALDR_HUMANENSP00000303356STRING
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Disease Reference
Kegg disease
H01065 Pentosuria
OMIM disease
260800Pentosuria (PNTSU)
Drug Reference
There are no disease associations of PTM sites.
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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides.";
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.;
Nat. Biotechnol. 21:566-569(2003).
Cited for: PROTEIN SEQUENCE OF 1-8, AND ACETYLATION AT MET-1.
Phosphorylation
ReferencePubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-149, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures