Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Glutamate dehydrogenase 1, mitochondrial  

UniProtKB / Swiss-Prot ID :  DHE3_BOVIN

Gene Name (Synonyms) : 
GLUD1, GLUD  

Species :  Bos taurus (Bovine). 

Subcellular Localization :  Mitochondrion matrix. 

Protein Function :  May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). 

Protein Sequence MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLVPPARRHYSEAAADREDDPNFFKMV...
Predicted Secondary Structure CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
84N6-acetyllysine; alternate.IVEDKLVED
HHHHHHHHH
40.71UniProtKB
Link
84N6-succinyllysine; alternate.IVEDKLVED
HHHHHHHHH
40.71UniProtKB
Link
90N6-acetyllysine.VEDLKTRET
HHHHHHHHH
58.83UniProtKB
Link
110N6-acetyllysine; alternate.LRIIKPCNH
HHHHCCCCE
40.94UniProtKB
Link
110N6-succinyllysine; alternate.LRIIKPCNH
HHHHCCCCE
40.94UniProtKB
Link
162N6-acetyllysine; alternate.VDEVKALAS
HHHHHHHHH
35.32UniProtKB
Link
162N6-succinyllysine; alternate.VDEVKALAS
HHHHHHHHH
35.32UniProtKB
Link
183N6-acetyllysine.FGGAKAGVK
CCCCCEEEE
49.28UniProtKB
Link
191N6-acetyllysine.KINPKNYTD
EECCCCCCH
59.09UniProtKB
Link
363N6-acetyllysine; alternate.LGFPKAKIY
EECCCCCCC
61.11UniProtKB
Link
363N6-succinyllysine; alternate.LGFPKAKIY
EECCCCCCC
61.11UniProtKB
Link
365N6-acetyllysine.FPKAKIYEG
CCCCCCCCC
52.53UniProtKB
Link
386N6-acetyllysine.AASEKQLTK
CCCCCCCCH
48.38UniProtKB
Link
399N6-acetyllysine.RVKAKIIAE
HCCEEEEEE
29.00UniProtKB
Link
415N6-acetyllysine; alternate.PEADKIFLE
HHHHHHHHH
42.26UniProtKB
Link
415N6-succinyllysine; alternate.PEADKIFLE
HHHHHHHHH
42.26UniProtKB
Link
457N6-acetyllysine; alternate.RLTFKYERD
HHHHHHHHH
40.75UniProtKB
Link
457N6-malonyllysine; alternate.RLTFKYERD
HHHHHHHHH
40.75UniProtKB
Link
457N6-succinyllysine; alternate.RLTFKYERD
HHHHHHHHH
40.75UniProtKB
Link
480N6-acetyllysine.RKFGKHGGT
HHHCCCCCC
42.06UniProtKB
Link
503N6-acetyllysine; alternate.GASEKDIVH
HHHHHCCCC
50.70UniProtKB
Link-
503N6-malonyllysine; alternate.GASEKDIVH
HHHHHCCCC
50.70UniProtKB
Link-
503N6-succinyllysine; alternate.GASEKDIVH
HHHHHCCCC
50.70UniProtKB
Link-
527N6-acetyllysine; alternate.RTAMKYNLG
HHHHHCCCC
28.64UniProtKB
Link-
527N6-malonyllysine; alternate.RTAMKYNLG
HHHHHCCCC
28.64UniProtKB
Link-
527N6-succinyllysine; alternate.RTAMKYNLG
HHHHHCCCC
28.64UniProtKB
Link-
545N6-acetyllysine; alternate.NAIEKVFRV
HHHHHHHHH
40.33UniProtKB
Link-
545N6-succinyllysine; alternate.NAIEKVFRV
HHHHHHHHH
40.33UniProtKB
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Sirt5 is a NAD-dependent protein lysine demalonylase anddesuccinylase.";
Du J., Zhou Y., Su X., Yu J.J., Khan S., Jiang H., Kim J., Woo J.,Kim J.H., Choi B.H., He B., Chen W., Zhang S., Cerione R.A.,Auwerx J., Hao Q., Lin H.;
Science 334:806-809(2011).
Cited for: ACETYLATION AT LYS-84; LYS-90; LYS-110; LYS-162; LYS-183; LYS-191;LYS-363; LYS-365; LYS-386; LYS-399; LYS-415; LYS-457; LYS-480;LYS-503; LYS-527 AND LYS-545, MALONYLATION AT LYS-457; LYS-503 ANDLYS-527, AND SUCCINYLATION AT LYS-84; LYS-110; LYS-162; LYS-363;LYS-415; LYS-457; LYS-503; LYS-527 AND LYS-545.
N6-malonyllysine
ReferencePubMed
"Sirt5 is a NAD-dependent protein lysine demalonylase anddesuccinylase.";
Du J., Zhou Y., Su X., Yu J.J., Khan S., Jiang H., Kim J., Woo J.,Kim J.H., Choi B.H., He B., Chen W., Zhang S., Cerione R.A.,Auwerx J., Hao Q., Lin H.;
Science 334:806-809(2011).
Cited for: ACETYLATION AT LYS-84; LYS-90; LYS-110; LYS-162; LYS-183; LYS-191;LYS-363; LYS-365; LYS-386; LYS-399; LYS-415; LYS-457; LYS-480;LYS-503; LYS-527 AND LYS-545, MALONYLATION AT LYS-457; LYS-503 ANDLYS-527, AND SUCCINYLATION AT LYS-84; LYS-110; LYS-162; LYS-363;LYS-415; LYS-457; LYS-503; LYS-527 AND LYS-545.
N6-succinyllysine
ReferencePubMed
"Sirt5 is a NAD-dependent protein lysine demalonylase anddesuccinylase.";
Du J., Zhou Y., Su X., Yu J.J., Khan S., Jiang H., Kim J., Woo J.,Kim J.H., Choi B.H., He B., Chen W., Zhang S., Cerione R.A.,Auwerx J., Hao Q., Lin H.;
Science 334:806-809(2011).
Cited for: ACETYLATION AT LYS-84; LYS-90; LYS-110; LYS-162; LYS-183; LYS-191;LYS-363; LYS-365; LYS-386; LYS-399; LYS-415; LYS-457; LYS-480;LYS-503; LYS-527 AND LYS-545, MALONYLATION AT LYS-457; LYS-503 ANDLYS-527, AND SUCCINYLATION AT LYS-84; LYS-110; LYS-162; LYS-363;LYS-415; LYS-457; LYS-503; LYS-527 AND LYS-545.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures