Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Dipeptidyl peptidase 3  

UniProtKB / Swiss-Prot ID :  DPP3_HUMAN

Gene Name (Synonyms) : 
DPP3  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Cytoplasm. 

Protein Function :  Cleaves Arg-Arg-beta-naphthylamide. 

Protein Sequence MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQ...
Predicted Secondary Structure CCCCCEECCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCC...
Protein Variant
LocationDescription
76R -> H (in dbSNP:rs11826683). VAR_033494
145Q -> H (in dbSNP:rs11550299). VAR_033495
678R -> H (in dbSNP:rs2305535). VAR_021850
690E -> K (in dbSNP:rs12421620). VAR_051597
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
Protein Variant
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)FGDTKFVPN
CCCCCCCCC
49.45Phosphositeplus
Link
202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)TRLFKEVDG
HHHHEEECC
62.51Phosphositeplus
Link
209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)DGEGKPYYE
CCCCCEEEE
26.08Phosphositeplus
Link
233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)EVTSKLKSY
EEECCEEEE
51.04Phosphositeplus
Link
235Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)TSKLKSYEF
ECCEEEEEE
55.52Phosphositeplus
Link
257Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)PILQKVVEQ
HHHHHHHHH
44.81Phosphositeplus
Link
264Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)EQLEKAKAY
HHHHHHHHH
64.87Phosphositeplus
Link
337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)AVVNKAMSA
EEECCHHHH
33.58Phosphositeplus
Link
425PhosphothreonineREKLTFLEE
CCCCCCCCC
36.92PhosphoELM
Link
425PhosphothreonineREKLTFLEE
CCCCCCCCC
36.92Phosphositeplus
Link
425Phosphothreonine.REKLTFLEE
CCCCCCCCC
36.92UniProtKB
Link
466Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)VQDEKGAFN
EEECCCCCC
64.92Phosphositeplus
Link
629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)LQVLKSTGD
HHHHHCCCC
47.30Phosphositeplus
Link
727Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)ARFWKGPSE
HHHCCCCCC
59.23Phosphositeplus
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
BBS2_HUMANENSP00000353701STRING
MKKS_HUMANENSP00000353701STRING
BBS7_HUMANENSP00000353701STRING
BBS4_HUMANENSP00000353701STRING
BBS5_HUMANENSP00000353701STRING
TTC8_HUMANENSP00000353701STRING
ARL6_HUMANENSP00000353701STRING
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Disease Reference
Kegg disease
There are no disease associations of PTM sites.
Drug Reference
There are no disease associations of PTM sites.
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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global phosphoproteome analysis on human HepG2 hepatocytes usingreversed-phase diagonal LC.";
Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K.,Demol H., Martens L., Goethals M., Vandekerckhove J.;
Proteomics 5:3589-3599(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-425, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures