Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Eukaryotic translation initiation factor 3 subunit F  

UniProtKB / Swiss-Prot ID :  EIF3F_MOUSE

Gene Name (Synonyms) : 
Eif3f, Eif3s5  

Species :  Mus musculus (Mouse). 

Subcellular Localization :  Cytoplasm (Probable). 

Protein Function :  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling (By similarity). 

Protein Sequence MASPAVPANVPPATAAAAPAPVVTAAPASAPTPSTPAPTPAATPAASPAPVSSDPAVAAPAAPGQTPASA...
Predicted Secondary Structure  -
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)RMSIKAYVS
26.76Phosphositeplus
Link-
242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)PLTVKYAYY
20.94Phosphositeplus
Link-
258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)DLIMKTCFS
34.84Phosphositeplus
Link-
262PhosphoserineKTCFSPNRV
24.34Phosphositeplus
Link-
301Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)VLSGKVSAD
29.64Phosphositeplus
Link-
321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)NQVPKIVPD
58.44Phosphositeplus
Link-
357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)ALNEKLVNL
57.57Phosphositeplus
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures