| Protein Name :
Histone acetyltransferase ESA1
UniProtKB / Swiss-Prot ID : ESA1_YEAST
Gene Name (Synonyms) :
ESA1 YOR244W O5257
Species : Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Subcellular Localization :
Protein Function : Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.