Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Guanine nucleotide-binding protein subunit alpha-12  

UniProtKB / Swiss-Prot ID :  GNA12_MOUSE

Gene Name (Synonyms) : 
Gna12, Gna-12  

Species :  Mus musculus (Mouse). 

Subcellular Localization :  Membrane; Lipid-anchor. 

Protein Function :  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 

Protein Sequence MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKST...
Predicted Secondary Structure CCHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
11S-palmitoyl cysteine.TLSRCLLPA
HHHHHCCCC
4.04UniProtKB
Link-
38PhosphoserineARRRSRDID
HHHHHHHHH
32.28Phosphositeplus
Link-
38Phosphoserine.ARRRSRDID
HHHHHHHHH
32.28UniProtKB
Link-
66PhosphoserineGAGESGKST
CCCCCCHHH
51.07Phosphositeplus
Link-
367PhosphothreonineAVKDTILQE
HHHHHHHHH
20.19Phosphositeplus
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
Palmitoylation
ReferencePubMed
"Galpha12 requires acylation for its transforming activity.";
Jones T.L., Gutkind J.S.;
Biochemistry 37:3196-3202(1998).
Cited for: PALMITOYLATION AT CYS-11, AND MUTAGENESIS OF SER-2; ARG-6 AND CYS-11.
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures