Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Histone-lysine N-methyltransferase MLL4  

UniProtKB / Swiss-Prot ID :  MLL4_MOUSE

Gene Name (Synonyms) : 
Wbp7, Mll2, Trx2  

Species :  Mus musculus (Mouse). 

Subcellular Localization :  Nucleus (By similarity). 

Protein Function :  Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). 

Protein Sequence MAAAAGGGSCPGPGSARGRFPGRPRGSGGGGGRGGRGNGAERVRVALRRGGGAAGPGGAEPGEDTALLRL...
Predicted Secondary Structure  -
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
113PhosphoserinePEEESSDGE
36.69Phosphositeplus
Link-
114PhosphoserineEEESSDGES
53.57Phosphositeplus
Link-
118PhosphoserineSDGESEEEE
56.70Phosphositeplus
Link-
185PhosphothreonineGEEGTERMV
24.57Phosphositeplus
Link-
320Phosphoserine.MGQLSQELE
17.45UniProtKB
Link-
467PhosphoserineKQEESPPLV
30.94Phosphositeplus
Link-
579PhosphoserinePVATSPPAP
21.10Phosphositeplus
Link-
590PhosphoserinePVPVSSPPR
30.93Phosphositeplus
Link-
597PhosphothreoninePRVPTPPST
45.00Phosphositeplus
Link-
639PhosphoserinePPAPSPPPA
52.74Phosphositeplus
Link-
784PhosphoserineARVASLGSL
30.33Phosphositeplus
Link-
787PhosphoserineASLGSLPLS
31.91Phosphositeplus
Link-
826PhosphoserineSMPLSPAVQ
12.63Phosphositeplus
Link-
849PhosphoserineGCVRSEDES
29.06Phosphositeplus
Link-
866PhosphoserineSGPESPLQG
33.76Phosphositeplus
Link-
1037PhosphoserineLPWDSDESP
39.13Phosphositeplus
Link-
1040PhosphoserineDSDESPEAS
32.79Phosphositeplus
Link-
1044PhosphoserineSPEASPGPP
28.82Phosphositeplus
Link-
1091PhosphoserineKQRPSYDVF
35.83Phosphositeplus
Link-
1098PhosphoserineVFEDSDDSE
35.80Phosphositeplus
Link-
1098PhosphoserineVFEDSDDSE
35.80SysPTM
Link-
1101PhosphoserineDSDDSEPGG
51.16Phosphositeplus
Link-
1101PhosphoserineDSDDSEPGG
51.16SysPTM
Link-
1917PhosphothreonineSPLATRPPP
51.93Phosphositeplus
Link-
1922PhosphoserineRPPPSRRTS
39.92Phosphositeplus
Link-
1927PhosphoserineRRTSSPLRT
27.60PhosphoELM
Link-
1927PhosphoserineRRTSSPLRT
27.60Phosphositeplus
Link-
1927PhosphoserineRRTSSPLRT
27.60SysPTM
Link-
1927Phosphoserine.RRTSSPLRT
27.60UniProtKB
Link-
1931PhosphothreonineSPLRTSPQL
53.06Phosphositeplus
Link-
1931PhosphothreonineSPLRTSPQL
53.06SysPTM
Link-
1932PhosphoserinePLRTSPQLR
12.29Phosphositeplus
Link-
1932PhosphoserinePLRTSPQLR
12.29SysPTM
Link-
2064PhosphothreonineVDDGTDSEA
43.26Phosphositeplus
Link-
2066PhosphoserineDGTDSEAEA
38.25Phosphositeplus
Link-
2079PhosphothreonineRGQGTPPSG
24.92Phosphositeplus
Link-
2281PhosphothreonineKRVSTFSGR
20.97Phosphositeplus
Link-
2283PhosphoserineVSTFSGRSP
33.13Phosphositeplus
Link-
2286PhosphoserineFSGRSPPVP
36.76Phosphositeplus
Link-
2346PhosphoserinePEEESPGRP
35.61Phosphositeplus
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1927, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures