Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Nucleoside diphosphate kinase B  

UniProtKB / Swiss-Prot ID :  NDKB_MOUSE

Gene Name (Synonyms) : 
Nme2  

Species :  Mus musculus (Mouse). 

Subcellular Localization :  Cytoplasm. Cell membrane. 

Protein Function :  Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Exhibits histidine protein kinase activity (By similarity). 

Protein Sequence MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNS...
Predicted Secondary Structure CCCHHHHHHHCCCCHHCCCCHHHHHHHHHHCCCCEEHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCC...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
94PhosphothreonineMLGETNPAD
HHCCCCHHH
44.71Phosphositeplus
Link-
94Phosphothreonine.MLGETNPAD
HHCCCCHHH
44.71UniProtKB
Link-
120PhosphoserineIIHGSDSVE
EEECCCCHH
16.73Phosphositeplus
Link-
122PhosphoserineHGSDSVESA
ECCCCHHHH
29.49Phosphositeplus
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures