Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Nuclear protein localization protein 4 homolog  

UniProtKB / Swiss-Prot ID :  NPL4_HUMAN

Gene Name (Synonyms) : 
NPLOC4, KIAA1499, NPL4  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By similarity). Note=Associated with the endoplasmic reticulum and nuclear (By similarity). 

Protein Function :  The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). 

Protein Sequence MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIK...
Predicted Secondary Structure CCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHCCHHHHHCCC...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
2N-acetylalanine.---MAESII
---CCCEEE
21.17UniProtKB
Link-
11PhosphoserineIRVQSPDGV
EEEECCCCC
23.31HPRD
Link-
188S-nitrosocysteineENISCKIKS
CCCCEEECC
4.71dbSNO
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
UFD1_HUMANyeast 2-hybridHPRD:06975HPRD11574150
TERA_HUMANENSP00000331487STRING
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Disease Reference
Kegg disease
There are no disease associations of PTM sites.
Drug Reference
There are no disease associations of PTM sites.
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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures