Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Neuraminidase  

UniProtKB / Swiss-Prot ID :  NRAM_I75A5

Gene Name (Synonyms) : 
NA  

Species :  Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9). 

Subcellular Localization :  Virion membrane (By similarity). Host apical cell membrane; Single-pass type II membrane protein (By similarity). Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses 

Protein Function :  Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication. 

Transmembrane Topology (topPTM) : NRAM_I75A5 

Protein Sequence MNPNQKILCTSATALVIGTIAVLIGITNLGLNIGLHLKPSCNCSHSQPEATNASQTIINNYYNDTNITQI...
Predicted Secondary Structure  -
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
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Experimental PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
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Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
63N-linked (GlcNAc...); by hostNNYYNDTNI
38.99UniProtKB
Link-
66N-linked (GlcNAc...); by hostYNDTNITQI
37.87UniProtKB
Link-
87N-linked (GlcNAc...); by host.RDFNNLTKG
49.43UniProtKB
Link
147N-linked (GlcNAc...); by host.GKHSNGTIH
51.88UniProtKB
Link
202N-linked (GlcNAc...); by host.GPNNNASAV
41.74UniProtKB
Link
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
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      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures