| Protein Name :
Serine/threonine-protein kinase N1
UniProtKB / Swiss-Prot ID : PKN1_MOUSE
Gene Name (Synonyms) :
Pkn1, Pkn, Prk1, Prkcl1
Species : Mus musculus (Mouse).
Subcellular Localization : Cytoplasm (By similarity). Nucleus (By similarity). Endosome (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Cleavage furrow (By similarity). Midbody (By similarity). Note=Associates with chromatin in a ligand-dependent manne
Protein Function : PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170', and GFAP. Able to phosphorylate RPS6 in vitro (By similarity).