Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Proteasome activator complex subunit 3  

UniProtKB / Swiss-Prot ID :  PSME3_MOUSE

Gene Name (Synonyms) : 
Psme3  

Species :  Mus musculus (Mouse). 

Subcellular Localization :  Nucleus. Cytoplasm. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. 

Protein Function :  Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation (By similarity). 

Protein Sequence MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPI...
Predicted Secondary Structure CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
23PhosphothreonineRERITSEAE
HHHHHHHHH
27.08Phosphositeplus
Link-
24PhosphoserineERITSEAED
HHHHHHHHH
32.22Phosphositeplus
Link-
205PhosphothreonineDYRRTVTEI
HHHHHHHHH
23.84PhosphoELM
Link-
205PhosphothreonineDYRRTVTEI
HHHHHHHHH
23.84Phosphositeplus
Link-
205PhosphothreonineDYRRTVTEI
HHHHHHHHH
23.84SysPTM
Link-
205Phosphothreonine.DYRRTVTEI
HHHHHHHHH
23.84UniProtKB
Link-
207PhosphothreonineRRTVTEIDE
HHHHHHHHH
26.98PhosphoELM
Link-
207PhosphothreonineRRTVTEIDE
HHHHHHHHH
26.98Phosphositeplus
Link-
207PhosphothreonineRRTVTEIDE
HHHHHHHHH
26.98SysPTM
Link-
207Phosphothreonine.RRTVTEIDE
HHHHHHHHH
26.98UniProtKB
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Drug Reference
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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205 AND THR-207, ANDMASS SPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures