Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Ras-related protein Rab-2A  

UniProtKB / Swiss-Prot ID :  RAB2A_HUMAN

Gene Name (Synonyms) : 
RAB2A, RAB2  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor (Potential). Golgi apparatus membrane; Lipid-anchor (Potential). Note=Identified by mass spectrometry in melanosome frac 

Protein Function :  Required for protein transport from the endoplasmic reticulum to the Golgi complex. 

Protein Sequence MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRS...
Predicted Secondary Structure CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCEEEEEEEEECCCCHHHHH...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
2N-acetylalanine.---MAYAYL
---CCCCEE
9.54UniProtKB
Link
3Phosphotyrosine--MAYAYLF
--CCCCEEE
8.42HPRD
Link
3Phosphotyrosine--MAYAYLF
--CCCCEEE
8.42Phosphositeplus
Link
15PhosphothreonineIIGDTGVGK
EEECCCCCH
28.67Phosphositeplus
Link
20PhosphoserineGVGKSCLLL
CCCHHHHHH
12.22HPRD
Link
53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)TIDGKQIKL
EECCEEEEE
45.14Phosphositeplus
Link
130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)RREVKKEEG
CCCCCHHHH
50.11Phosphositeplus
Link
165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)INTAKEIYE
HHHHHHHHH
42.48Phosphositeplus
Link
211S-geranylgeranyl cysteine.AGGGCC
CCCCCC
2.55UniProtKB
Link-
212S-geranylgeranyl cysteine.GGGCC
CCCCC
7.65UniProtKB
Link
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
FA71C_HUMANphysical interactionEBI-760075
intact16189514
FA71C_HUMANyeast 2-hybridHPRD:01539HPRD16189514
GORS2_HUMANin vitroHPRD:01539HPRD11739401
GORS2_HUMANENSP00000262646STRING
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Disease Reference
Kegg disease
There are no disease associations of PTM sites.
Drug Reference
There are no disease associations of PTM sites.
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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
Prenylation
ReferencePubMed
"Isoprenoid modification of rab proteins terminating in CC or CXCmotifs.";
Khosravi-Far R., Lutz R.J., Cox A.D., Conroy L., Bourne J.R.,Sinensky M., Balch W.E., Buss J.E., Der C.J.;
Proc. Natl. Acad. Sci. U.S.A. 88:6264-6268(1991).
Cited for: ISOPRENYLATION AT CYS-211 AND CYS-212.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures