Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Ras-related protein Rab-11A  

UniProtKB / Swiss-Prot ID :  RB11A_HUMAN

Gene Name (Synonyms) : 
RAB11A, RAB11  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to th 

Protein Function :  Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). 

Protein Sequence MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQ...
Predicted Secondary Structure CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEECCCC...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
2N-acetylglycine.---MGTRDD
---CCCCCC
29.47UniProtKB
Link-
8PhosphotyrosineRDDEYDYLF
CCCCCCCEE
19.51HPRD
Link
8PhosphotyrosineRDDEYDYLF
CCCCCCCEE
19.51Phosphositeplus
Link
42PhosphoserineLESKSTIGV
CCCCCCCEE
34.24Phosphositeplus
Link
43PhosphothreonineESKSTIGVE
CCCCCCEEE
26.03Phosphositeplus
Link
50PhosphothreonineVEFATRSIQ
EEEEEEEEE
30.21Phosphositeplus
Link
73PhosphotyrosineGQERYRAIT
CCHHHHHHH
12.02Phosphositeplus
Link
78PhosphoserineRAITSAYYR
HHHHHHHHC
14.25Phosphositeplus
Link
177PhosphoserineYRIVSQKQM
HHHHHCCCC
29.32Phosphositeplus
Link-
179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)IVSQKQMSD
HHHCCCCCC
40.22Phosphositeplus
Link-
190PhosphoserineENDMSPSNN
HCCCCCCCC
28.21HPRD
Link-
192PhosphoserineDMSPSNNVV
CCCCCCCCC
33.46HPRD
Link-
207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)TTENKPKVQ
CCCCCCCCC
39.73Phosphositeplus
Link-
212S-farnesyl cysteinePKVQCCQNI
CCCCCCCCC
2.63HPRD
Link-
213S-farnesyl cysteineKVQCCQNI
CCCCCCCC
1.62HPRD
Link-
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
RAB4A_HUMANcolocalizationMINT-3369790MINT16962593
R3GEF_HUMANphysical interactionMINT-66622MINT16189514
DTBP1_HUMANphysical interactionEBI-1106257
intact17043677
RFIP1_HUMANphysical interactionEBI-1060613
intact17353931
PSN1_HUMANin vivo
yeast 2-hybrid
HPRD:05715HPRD10369872
STX4_HUMANin vitroHPRD:05715HPRD12435603
PSN2_HUMANin vivo
yeast 2-hybrid
HPRD:05715HPRD10369872
GDIB_HUMANin vitroHPRD:05715HPRD10512627
RB11A_HUMANin vitroHPRD:05715HPRD14699104
WDR44_HUMANENSP00000261890STRING
RFIP5_HUMANENSP00000261890STRING
RFIP3_HUMANENSP00000261890STRING
PI4KB_HUMANENSP00000261890STRING
MYO5B_HUMANENSP00000261890STRING
RFIP4_HUMANENSP00000261890STRING
RFIP1_HUMANENSP00000261890STRING
RGN_HUMANENSP00000261890STRING
RFIP2_HUMANENSP00000261890STRING
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Disease Reference
Kegg disease
There are no disease associations of PTM sites.
Drug Reference
There are no disease associations of PTM sites.
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Related Literatures of Post-Translational Modification
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures