Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  O-phosphoseryl-tRNA(Sec) selenium transferase  

UniProtKB / Swiss-Prot ID :  SPCS_HUMAN

Gene Name (Synonyms) : 
SEPSECS, TRNP48  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Cytoplasm. 

Protein Function :  Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. 

Protein Sequence MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNC...
Predicted Secondary Structure CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC...
Protein Variant
LocationDescription
239A -> T (in PCH2D; abrogates enzymeactivity).
334Y -> C (in PCH2D; abrogates enzymeactivity).
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
Protein Variant
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
118PhosphothreonineLNKITNSLV
HHHHHHHHH
21.99Phosphositeplus
Link
120PhosphoserineKITNSLVLD
HHHHHHHHH
15.94Phosphositeplus
Link
284N6-(pyridoxal phosphate)lysine.QSLDKNFMV
ECCCCCCCC
58.33UniProtKB
Link
315PhosphoserinePGRASASPS
CCCCCCCHH
28.11Phosphositeplus
Link
317PhosphoserineRASASPSLD
CCCCCHHHH
16.72Phosphositeplus
Link
325PhosphothreonineDVLITLLSL
HHHHHHHHH
19.93Phosphositeplus
Link
328PhosphoserineITLLSLGSN
HHHHHHCCH
33.52Phosphositeplus
Link
501PhosphoserineQDASS
CCCCC
46.06HPRD
Link
501Phosphoserine.QDASS
CCCCC
46.06UniProtKB
Link
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
There are no Protein-Protein Interactions.
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Disease Reference
Kegg disease
OMIM disease
613811Pontocerebellar hypoplasia 2D (PCH2D)
Drug Reference
There are no disease associations of PTM sites.
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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures