Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Glutamine--tRNA ligase  

UniProtKB / Swiss-Prot ID :  SYQ_HUMAN

Gene Name (Synonyms) : 
QARS  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Cytoplasm. 

Protein Function :   

Protein Sequence MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLASRLRDTRRLS...
Predicted Secondary Structure CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHH...
Protein Variant -
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
2N-acetylalanine.---MAALDS
---CCHHHH
19.41UniProtKB
Link
6PhosphoserineAALDSLSLF
CHHHHHHHH
22.25HPRD
Link
6PhosphoserineAALDSLSLF
CHHHHHHHH
22.25Phosphositeplus
Link
11PhosphothreonineLSLFTSLGL
HHHHHHCCC
28.47HPRD
Link
16PhosphoserineSLGLSEQKA
HCCCCHHHH
35.86HPRD
Link
16PhosphoserineSLGLSEQKA
HCCCCHHHH
35.86Phosphositeplus
Link
25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)RETLKNSAL
HHHHHHHHH
57.17Phosphositeplus
Link
70PhosphoserineTRRLSFLVS
CCCHHHHHH
18.09HPRD
Link
70PhosphoserineTRRLSFLVS
CCCHHHHHH
18.09PhosphoELM
Link
70PhosphoserineTRRLSFLVS
CCCHHHHHH
18.09Phosphositeplus
Link
70Phosphoserine.TRRLSFLVS
CCCHHHHHH
18.09UniProtKB
Link
74PhosphoserineSFLVSYIAS
HHHHHHHHC
16.99Phosphositeplus
Link
142PhosphotyrosineLVERYHFNM
HHHHHCCCH
9.39Phosphositeplus
Link
205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)RRTAKDVVE
CCCCCCCCC
50.90Phosphositeplus
Link
309N6-acetyllysineTNPEKEEAK
CCCCCCCHH
63.21HPRD
Link
309N6-acetyllysineTNPEKEEAK
CCCCCCCHH
63.21Phosphositeplus
Link
309N6-acetyllysine.TNPEKEEAK
CCCCCCCHH
63.21UniProtKB
Link
366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)GEELKGHNT
HHHHHHHHH
62.49Phosphositeplus
Link
394Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)MRKGKFSEG
HHHCCCCCC
49.07Phosphositeplus
Link
412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)MEDGKMDPV
CCCCEEEEE
53.07Phosphositeplus
Link
477PhosphotyrosineALDVYCPVQ
HCCCCCCEE
7.24Phosphositeplus
Link
484PhosphotyrosineVQWEYGRLN
EEEEECCCC
12.46Phosphositeplus
Link
491PhosphotyrosineLNLHYAVVS
CCCCCCCCC
12.31HPRD
Link
491PhosphotyrosineLNLHYAVVS
CCCCCCCCC
12.31HPRD
Link
491PhosphotyrosineLNLHYAVVS
CCCCCCCCC
12.31PhosphoELM
Link
491PhosphotyrosineLNLHYAVVS
CCCCCCCCC
12.31Phosphositeplus
Link
491Phosphotyrosine.LNLHYAVVS
CCCCCCCCC
12.31UniProtKB
Link
505PhosphothreonineQLVATGAVR
CCCCCCCCC
20.42HPRD
Link
505PhosphothreonineQLVATGAVR
CCCCCCCCC
20.42Phosphositeplus
Link
586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)FPAAKSLDI
CCCCCEEEE
54.37Phosphositeplus
Link
620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)RTDFKEEPE
CCCCCCCCC
65.07Phosphositeplus
Link
620N6-acetyllysineRTDFKEEPE
CCCCCCCCC
65.07HPRD
Link
620N6-acetyllysineRTDFKEEPE
CCCCCCCCC
65.07Phosphositeplus
Link
620N6-acetyllysine.RTDFKEEPE
CCCCCCCCC
65.07UniProtKB
Link
628Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)EPGFKRLAW
CCCCEEECC
53.03Phosphositeplus
Link
769Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)TVTLKEDPG
EEEECCCCC
51.19Phosphositeplus
Link
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
DUS11_HUMANphysical interactionMINT-63202MINT16169070
BAT2_HUMANphysical interactionMINT-62732MINT14667819
BAT2_HUMANphysical interactionMINT-62808MINT14667819
Q5T5T6_HUMANphysical interactionMINT-66862MINT16189514
Q6XYD2_HUMANphysical interactionMINT-67714MINT16189514
CPNE3_HUMANphysical interactionEBI-734197
intact16169070
SYRC_HUMANin vitroHPRD:07223HPRD10801842
M3K5_HUMANin vitro
in vivo
HPRD:07223HPRD11096076
SMAD9_HUMANyeast 2-hybridHPRD:07223HPRD15231748
DUS11_HUMANyeast 2-hybridHPRD:07223HPRD16169070
CPNE3_HUMANyeast 2-hybridHPRD:07223HPRD16169070
SYRC_HUMANENSP00000307567STRING
GFPT2_HUMANENSP00000307567STRING
SYMC_HUMANENSP00000307567STRING
SYDC_HUMANENSP00000307567STRING
PUR1_HUMANENSP00000307567STRING
PYR1_HUMANENSP00000307567STRING
GUAA_HUMANENSP00000307567STRING
GLSL_HUMANENSP00000307567STRING
GLSK_HUMANENSP00000307567STRING
NADE1_HUMANENSP00000307567STRING
GLNA_HUMANENSP00000307567STRING
GFPT1_HUMANENSP00000307567STRING
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Disease Reference
Kegg disease
OMIM disease
615760Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)
Drug Reference
DrugBank
DB00130L-Glutamine
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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-309 AND LYS-620, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-491, AND MASSSPECTROMETRY.
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-491, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND MASSSPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures