Species : Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Subcellular Localization : Nucleus (By similarity). Chromosome, telomere (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the
Protein Function : Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity).