Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures
Basic Information
Protein Name :  Acetyl-CoA acetyltransferase, mitochondrial  

UniProtKB / Swiss-Prot ID :  THIL_HUMAN

Gene Name (Synonyms) : 
ACAT1, ACAT, MAT  

Species :  Homo sapiens (Human). 

Subcellular Localization :  Mitochondrion. 

Protein Function :  Plays a major role in ketone body metabolism. 

Protein Sequence MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLGSI...
Predicted Secondary Structure CHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHH...
Protein Variant
LocationDescription
5A -> P (in dbSNP:rs3741056). VAR_007496
85Missing (in 3KTD). VAR_007497
93N -> S (in 3KTD; 10% activity). VAR_007498
152G -> A (in 3KTD). VAR_007499
158N -> D (in 3KTD; no activity). VAR_007500
183G -> R (in 3KTD; no activity). VAR_007501
297T -> M (in 3KTD; 10% normal activity). VAR_007502
301A -> P (in 3KTD; 5% normal activity). VAR_007503
312I -> T (in 3KTD; 10% activity). VAR_007504
333A -> P (in 3KTD; no activity). VAR_007505
379G -> V (in 3KTD). VAR_007506
380A -> T (in 3KTD; 7% normal activity). VAR_007507
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Overview of Protein Modification Sites with Functional and Structural Information
Accessible Surface Area (ASA)
Pred. Secondary
Real Secondary
Disorder Prediction
Protein Domain
&
Experimental PTM Sites
Predicted PTM Sites
Protein Variant
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Experimental Post-Translational Modification Sites Download
Locations
Modification
Substrate Sites
&
Secondary Structure
Accessible Surface Area (%)
Resource
Reference
Structural Characterization
Orthologous
Protein Cluster
83N6-acetyllysineAGIPKEEVK
CCCCHHHHH
65.66HPRD
Link
83N6-acetyllysineAGIPKEEVK
CCCCHHHHH
65.66Phosphositeplus
Link
83N6-acetyllysine.AGIPKEEVK
CCCCHHHHH
65.66UniProtKB
Link
116PhosphoserineGLPISTPCT
CCCCCCCCE
25.10HPRD
Link
174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)YGGVKLEDL
CCCCCCHHH
49.81Phosphositeplus
Link
174N6-acetyllysineYGGVKLEDL
CCCCCCHHH
49.81HPRD
Link
174N6-acetyllysineYGGVKLEDL
CCCCCCHHH
49.81Phosphositeplus
Link
174N6-acetyllysine.YGGVKLEDL
CCCCCCHHH
49.81UniProtKB
Link
181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)DLIVKDGLT
HHHHCCCHH
38.80Phosphositeplus
Link
181N6-acetyllysineDLIVKDGLT
HHHHCCCHH
38.80HPRD
Link
181N6-acetyllysineDLIVKDGLT
HHHHCCCHH
38.80Phosphositeplus
Link
181N6-acetyllysine.DLIVKDGLT
HHHHCCCHH
38.80UniProtKB
Link
190N6-acetyllysineDVYNKIHMG
HHHCCCCCC
19.12HPRD
Link
202N6-acetyllysineENTAKKLNI
HHHHHHHCC
56.61HPRD
Link
251N6-acetyllysineDVVVKEDEE
EEEECCCCC
48.08HPRD
Link
251N6-acetyllysineDVVVKEDEE
EEEECCCCC
48.08Phosphositeplus
Link
251N6-acetyllysine.DVVVKEDEE
EEEECCCCC
48.08UniProtKB
Link
263N6-acetyllysineVDFSKVPKL
CCHHHHCCC
63.65HPRD
Link
263N6-acetyllysineVDFSKVPKL
CCHHHHCCC
63.65Phosphositeplus
Link
263N6-acetyllysine.VDFSKVPKL
CCHHHHCCC
63.65UniProtKB
Link
407PhosphotyrosineKQGEYGLAS
HCCCEEEEE
25.02Phosphositeplus
Link
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Protein-Protein Interactions
      Interacting Protein      
Interaction type
Source ID
      Resource      
      Pubmed ID      
Domain-Domain Interactions
HCD2_HUMANENSP00000265838STRING
SCOT_HUMANENSP00000265838STRING
DLDH_HUMANENSP00000265838STRING
ODPX_HUMANENSP00000265838STRING
ECHP_HUMANENSP00000265838STRING
ACADL_HUMANENSP00000265838STRING
ACADS_HUMANENSP00000265838STRING
DHB4_HUMANENSP00000265838STRING
DCMC_HUMANENSP00000265838STRING
ODP2_HUMANENSP00000265838STRING
THIM_HUMANENSP00000265838STRING
ODPAT_HUMANENSP00000265838STRING
ODPAT_HUMANENSP00000265838STRING
ODPAT_HUMANENSP00000265838STRING
ACOX1_HUMANENSP00000265838STRING
ACO12_HUMANENSP00000265838STRING
ODPB_HUMANENSP00000265838STRING
ACOX2_HUMANENSP00000265838STRING
ACS2L_HUMANENSP00000265838STRING
HMCS1_HUMANENSP00000265838STRING
AACS_HUMANENSP00000265838STRING
AACS_HUMANENSP00000265838STRING
AACS_HUMANENSP00000265838STRING
AACS_HUMANENSP00000265838STRING
AACS_HUMANENSP00000265838STRING
AACS_HUMANENSP00000265838STRING
AACS_HUMANENSP00000265838STRING
ECHB_HUMANENSP00000265838STRING
ACD10_HUMANENSP00000265838STRING
THIK_HUMANENSP00000265838STRING
ACACA_HUMANENSP00000265838STRING
ACOX3_HUMANENSP00000265838STRING
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Disease Reference
Kegg disease
OMIM disease
2037503-ketothiolase deficiency (3KTD)
Drug Reference
DrugBank
DB00795Sulfasalazine
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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-83; LYS-174; LYS-181;LYS-251 AND LYS-263, AND MASS SPECTROMETRY.
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Basic Information | Overview of PTM Sites | Experimental PTM Sites | Protein-Protein Interactions | Drug and Disease Associations | Related Literatures