statistics

The statistics of external PTM resource in dbPTM

Resource Description Version Statistics
UniProtKB Experimental Post-Translational Modifications (PTMs) Release 2015_08 65,090 PTM sites within 20,877 proteins
Putative PTMs 546,911 PTM sites within 369,106 proteins
Phospho.ELM Experimental phosphorylation sites Release 9.0 42,914 phosphorylation sites within 8,698 proteins
PhosphoSitePlus Phosphorylated protein and phosphorylation sites Release 20150915 456,436 modification sites within 52,095 proteins
OGlycBase Experimental glycosylation sites Release 6.0 2,353 PTM sites within 185 glycoproteins
dbSNO Experimental S-nitrosylated pretein and S-nitrosylated sites Release 2.0 4,165 known S-nitrosylated sites within 2,277 proteins
UbiProt Ubiquitylated protein and ubiquitylation sites Release 1.0 147 proteins contain 165 ubiquitylated sites
MeMo Methylated protein and Methylated sites Release 2.0 364 Methylated sites within 131 proteins
PupDB Pupylated protein and pupylation sites Release 1.3 311 known pupylated sites within 268 proteins
SysPTM Post-Translational Modifications protein and sites Release 2.0 514,766 PTM sites within 86,144 proteins
HPRD Experimental Post-Translational Modifications (PTMs) on Human proteins Release 9.0 93,710 modification sites within 30,047 proteins
dbGSH Experimental S-glutathionylated proteins and S-glutathionylated sites Release 1.0 4,119 S-glutathionylated sites within 2,326 proteins
mUbiSiDa Experimental Ubiquitination proteins and Ubiquitination sites in mammalian,especially in human Release 1.0 111,207 Ubiquitination sites within 35,494 proteins

Data statistics of benchmark dataset for nine PTM types with sufficient data.

PTM Type
Number of Proteins
Number of Positive sites
Number of Negative sites
Phosphorylation by PKA
143
191
4,910
Phosphorylation by CK2
73
97
2,168
Phosphorylation by PKC
84
105
2,982
Phosphorylation by CDK1
71
107
2,897
Phosphorylation by MAPK1
35
57
1,105
N-linked Glycosylation
1,790
3,797
64,185
Acetylation
1,881
3,243
134,830
O-linked Glycosylation
292
529
10,797
Amidation
88
125
1,593
Hydroxylation
140
226
3,865
Methylation
205
320
4,571
S-nitrosylation
43
50
303
N6-succinyllysine
399
1,106
4,260

The statistics of experimental and putative PTM sites in dbPTM

PTM Type
Number of experimental sites
Number of experimental sites from UniProtKB
Number of putative sites from UniProtKB
Number of putative sites by HMMs
Phosphorylation
258654
41083
96915
1414879
Ubiquitination
111207
-
-
8865
N-linked Glycosylation
103016
5172
100846
418253
Acetylation
35527
8829
53022
1156
O-linked Glycosylation
5729
1150
3204
373758
Amidation
4449
1886
1309
114034
Hydroxylation
3436
1504
5767
9743
Methylation
8096
1263
23070
22332
Pyrrolidone Carboxylic Acid
1679
629
748
12322
Sumoylation
1638
-
-
13042
Gamma-Carboxyglutamic Acid
1262
-
-
1942
4-carboxyglutamate
399
399
868
-
Palmitoylation
5576
-
-
33830
Sulfation
1019
-
-
70005
Sulfotyrosine
186
186
839
-
Myristoylation
1454
-
-
988
C-linked Glycosylation
255
152
59
3923
Prenylation
1459
-
-
6741
Nitration
190
51
280
1432
Deamidation
231
64
380
2022
S-nitrosylation
4165
64
459
-
Oxidation
1126
-
-
-
ADP-ribosylation
314
17
1082
-
N6-succinyllysine
4637
1381
5571
-
Formylation
190
64
40
-
GPI anchoring
0
-
-
-
N6-lipoyllysine
19
19
6357
-
Methyl ester
87
87
914
-
N6-crotonyllysine
342
342
213
-
Methionine sulfoxide
52
38
305
-
N6-glutaryllysine
43
43
81
-
4-aspartylphosphate
29
29
8732
-
Pyridoxal phosphate
6371
23
148475
-
Bromination
90
30
57
-
N6-malonyllysine
200
33
167
-
Citrullination
220
113
319
-
N6-carboxylysine
1608
37
20848
-
Glutathionylation
4119
31
35
-
FAD
183
1
766
-
Pupylation
268
-
-
Others
40512
370
65183
-
Total
610,037
65,090
546,911
2,509,267